Retrieval of monthly average hourly values of direct and diffuse solar irradiance from measurements of global radiation in Spain

An exhaustive evaluation of the performance of decomposition models to estimate direct and diffuse components from the global horizontal solar irradiance has been carried out in this work. The main objective of this work has been to compare the model performance for two different time bases, hourly and monthly average hourly bases. An extensive database of horizontal solar irradiance from nine locations in Spain was used for the study. The data span through January 1980 to December 2012 of hourly solar irradiance for the nine locations and thus indicate a cumulative year sum of 132 years. This study first investigated the decomposition of the hourly horizontal irradiance into hourly direct and diffuse components using six decomposition models widely referenced in the bibliography. In the hourly decomposition investigation, it was observed that there are no significant differences between the six models for each specific location. Nevertheless, the performance of each of the models was strongly dependent on cloudiness conditions and the solar altitude at the location which is associated with the climatic condition of each site. Further investigations using the six decomposition models were conducted to estimate monthly average hourly values of direct and diffuse components of the solar irradiance with proper assessment of the different models' performance at various locations. Based on the results of the investigations which present no significant differences in the performance of the different models, an extremely simple algorithm was developed to estimate monthly average hourly values of direct and diffuse solar irradiance, which reduces the statistical errors in all locations investigated.Spanish Government (ENE2014-54601R) and the 506 Regional Government of Castile and Leon (BU358A12-2

Mathematical interpolation methods for spatial estimation of global horizontal irradiation in Castilla-León, Spain: a case study

Four spatial interpolation methods (Inverse Distance Weighted, Spline, Kriging and Natural Neighbor) and their different variations are employed to map Global Horizontal Irradiation (GHI) in Castilla-León, Spain. The work has been performed using the software ArcGis, widely used in geostatistical applications, showing the versatility of the system and its applicability to climate data. The measuring network consists of 71 ground meteorological stations that use seven complete years of half-hourly data sets, yielding annual daily averages of GHI. The interpolation results are tested against data from the four Spanish National Meteorological Agency (AEMET) stations available in the region using standard statistical indicators (RMSE, MBE, MAPE and MAE). An additional partial cross validation of the results, which excludes five stations from the measuring network, employs different criteria to verify the results of the interpolation methods applied. This work contributes to the classification of interpolation methods to obtain climatological data across large areas with a low number of irregularly distributed of measurement points and with a low topographic complexity. The Universal Kriging method with quadratic semi-variogram shows the best results taking into account the RMSE and MAE statistical indicatorsSpanish Government (Grant ENE2014-54601-R) and Junta de Castilla- León (BU034U16). One of the authors, David González Peña, thanks to Junta de Castilla-León and European Social Fund (Orden EDU/310/2015) for financial support

El yacimiento kárstico del Pleistoceno Superior de la Cueva del Camino en el Calvero de la Higuera (Pinilla del Valle, Madrid)

Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Palaeontological analisis of the Late Pleistocene Site of Cova Foradada (Xábia, Alicante, Spain)

En este trabajo se presenta el estudio de la estratigrafía, secuencia polínica, taxonomía y tafonomía del yacimiento del Pleistoceno superior de Cova Foradada, Xábia (Alicante). Las especies de macromamíferos representadas en el yacimiento son, dentro de los carnívoros, Panthera pardus (Linnaeus, 1978), Lynx pardinus (Temminck, 1827) y Felis silvestris (Schreber, 1777); del grupo de los artiodáctilos, Cervus elaphus (Linnaeus, 1978), Capra pyrenaica (Schinz, 1838), Bos primigenius (Bojanus, 1827) y Sus scrofa (Linnaeus, 1978). Se han identificado dos especies de perisodáctilos Equus ferus (Boddaert , 1785) y Equus hydruntinus (Regalia, 1904). En todos los niveles del yacimiento se observa un claro predominio de los ungulados de talla media (Cervus elaphus) y talla pequeña (Capra pyrenaica). Los patrones de fracturación indican actividad humana y evidencian el aprovechamiento máximo de los recursos cárnicos. Se han encontrado marcas antrópicas en restos de lince, gato montés y leopardo. El análisis polínico pone de manifiesto el dominio de un paisaje muy abierto y empobrecido desde el punto de vista taxonómico.This study presents aspects related to the stratigraphy, pollen sequence, taxonomy and taphonomy of the Late Pleistocene site of Cova Foradada in Xábia (Alicante, Spain). The fossil material comes from Sector I of the site that comprises eight stratigraphic levels. Some of these levels have been previously dated (Casabó, 2001): 33,900 ± 310 B.P. for Level VII; 29,940 ± 150 B.P. for Level VI; 27,170 ± 150 B.P. and 29,420 ± 190 B.P. for Level V; and 6,130 ± 140 B.P. for Level III. The total number of identifiable remains represents a very low percentage of the total remains, mainly due to the high degree of fragmentation. The macrovertebrate fossils found are: Panthera pardus (Linnaeus, 1978), Lynx pardinus (Temminck, 1827) and Felis silvestris (Schreber, 1777) among the Carnivora; Cervus elaphus (Linnaeus, 1978), Capra pyrenaica (Schinz, 1838), Bos primigenius (Bojanus, 1827) and Sus scrofa (Linnaeus, 1978) among the Artiodactyla ; and Equus ferus (Boddaert , 1785) and Equus hydruntinus (Regalia, 1904) among the Perisodactyla. Mid- and small-sized ungulates are clearly predominant along the whole sequence, such as Cervus elaphus for the former, and Capra pyrenaica for the latter. The taphonomical analysis allows to discard carnivore activity as the accumulation agent. Signs of carnivore activity are scarce, and they are only present in Level V. Fracture pattern in the bones show human activity as the main agent, characterized by the maximum exploitation of meat resources. Anthropic marks have been found in lynx, wild cat and leopard remains. The patterns of the cuts on these remains are typical of the exploitation of both the flesh and the fleece of these animals. Regarding the paleoenvironmental aspects, the pollen data show predominance of an open environment, depleted from the taxonomical point of view. The detailed pollen analysis allows us to distinguish three levels: the base level shows a more abundant forest cover with Pinus and Juniperus as predominant taxa; the middle level shows signs of a more extreme climate period; and the uppermost level shows a phase of recovering of the flora, with a reduced forest and a varied herbaceous courtship (Apiaceae, Poaceae and Fabaceae).Depto. de Geodinámica, Estratigrafía y PaleontologíaFac. de Ciencias GeológicasTRUEpu

Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

Clonal evolution in acute myeloid leukemia (AML) originates long before diagnosis and is a dynamic process that may affect survival. However, it remains uninvestigated during routine diagnostic workups. We hypothesized that the mutational status of bone marrow dysplastic cells and leukemic blasts, analyzed at the onset of AML using integrated multidimensional flow cytometry (MFC) immunophenotyping and fluorescence-activated cell sorting (FACS) with next-generation sequencing (NGS), could reconstruct leukemogenesis. Dysplastic cells were detected by MFC in 285 of 348 (82%) newly diagnosed patients with AML. Presence of dysplasia according to MFC and World Health Organization criteria had no prognostic value in older adults. NGS of dysplastic cells and blasts isolated at diagnosis identified 3 evolutionary patterns: stable (n = 12 of 21), branching (n = 4 of 21), and clonal evolution (n = 5 of 21). In patients achieving complete response (CR), integrated MFC and FACS with NGS showed persistent measurable residual disease (MRD) in phenotypically normal cell types, as well as the acquisition of genetic traits associated with treatment resistance. Furthermore, whole-exome sequencing of dysplastic and leukemic cells at diagnosis and of MRD uncovered different clonal involvement in dysplastic myelo-erythropoiesis, leukemic transformation, and chemoresistance. Altogether, we showed that it is possible to reconstruct leukemogenesis in ∼80% of patients with newly diagnosed AML, using techniques other than single-cell multiomics.This work was supported by grants from the Área de Oncología del Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red (CIBER-ONC) (CB16/12/00369, CB16/12/00233, CB16/12/00489, and CB16/12/00284), Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS numbers PI16/01661, PI16/00517, and PI19/01518), and the Plan de Investigación de la Universidad de Navarra (PIUNA 2014-18). This work was supported internationally by the Cancer Research UK, FCAECC, and AIRC under the Accelerator Award Program (EDITOR)

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

¿Qué queda de mí?

Este libro es una reclamación a quienes hemos sido, somos o seremos docentes. A quienes no hemos respetado a las personas que se han puesto junto a nosotros y nosotras, confiando su bien más preciado: la libertad. Estas páginas denuncian cada vez que convertimos una visión en la visión, una emoción en la emoción, un saber en el saber, un comportamiento en el comportamiento. Es un grito contra la imposición, la normalización, la neutralización y la universalización de una perspectiva particular. Una pugna contra cada proceso que no se ha conectado con las vidas de los aprendices. Un texto colaborativo realizado por alumnado de Educación y Cambio Social en el Grado en Educación Infantil de la Universidad de Málaga y coordinado por Ignacio Calderón Almendros

Nutrición parenteral domiciliaria en España 2018. Informe del Grupo de Nutrición Artificial Domiciliaria y Ambulatoria NADYA

Aim: to communicate home parenteral nutrition (HPN) data obtained from the HPN registry of the NADYA-SENPE group (www.nadya-senpe. com) for the year 2018. Material and methods: descriptive analysis of the data collected from adult and pediatric patients with HPN in the NADYA-SENPE group registry from January 1st, 2018 to December 31st, 2018. Results: there were 278 patients from 45 Spanish hospitals (54.7 % women), 23 children and 255 adults, which represent a prevalence rate of 5.95 patients/million inhabitants/year 2018. The most frequent diagnosis in adults was " palliative cancer" (22.0 %), followed by "others". In children it was Hirschsprung's disease together with necrotizing enterocolitis, with four cases (17.4 %). The first indication was short bowel syndrome in both children (60.9 %) and adults (35.7 %). The most frequently used type of catheter was tunneled in both children (81.0 %) and adults (41.1 %). Ending 75 episodes, the most frequent cause was death (52.0 %) and change to oral feeding (33.3 %). Conclusions: the number of centers and collaborating professionals in the registry of patients receiving HPN remains stable, as well as the main indications and reasons for termination of HPN